Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :Desvenlafaxine93413-62-8HY-B0602263.38C16H25NO2>98%ySolubility:DMSO 37 mg/mL; Water <1 mg/mLg;gMechanisms: Pathways:Neuronal Signaling; Target:SSRIs Biological Activity:Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nMDesvenlafaxineisaserotonin(5HT)andnorepinephrine(NE)reuptakeinhibitorwithKiof402nMand 558.4 nM, respectively. Target: SSRIs Desvenlafaxine is a serotonin-norepinephrine reuptake inhibitor and is the active metabolite of theantidepressant venlafaxine. Similar to venlafaxine, desvenlafaxine inhibits the neuronal uptake ofserotonin and norepinephrine. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter. Desvenlafaxine inhibits [3H]5-HT or [3H]NE uptake forthe hSERT or hNET with IC50 of 47.3 and 531.3 nM, respectively. Desvenlafaxine rapidlypenetrates the male rat brain and hypothalamus. Desvenlafaxine significantly increases extracellularpypgyNE levels compared with baseline in the male rat hypothalamus but had no effect on DA levels usingmicrodialysis [1]. Desvenlafaxine has the potential to inhi...References:[1]. Deecher, D.C., et al., Desvenlafaxine succinate: A new serotonin and norepinephrine reuptakeinhibitor. J Pharmacol Exp Ther, 2006. 318(2): p. 657-65. [2]. Sopko, M.A., Jr., M.J. Ehret, and M. Grgas, Desvenlafaxine: another \"me too\" drug? AnnPharmacother, 2008. 42(10): p. 1439-46. Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com 18 Wilkinson Way, Princeton, NJ 08540,USAess.com Web: www.medchemexpress.comEmail: info@medchemexpr