专利名称：Gene therapy using tgf-beta
发明人：KWAN HEE LEE,MOON JONG NOH,KYOUNG
AE KANG
申请号：AU2002243307申请日：20011107公开号：AU2002243307A1公开日：20020724
摘要：The subject invention is related to a cell-mediated gene therapy treatment fororthopedic disease using a member belonging to the transforming growth factor-&bgr;(TGF-&bgr;) superfamily. TGF-&bgr; gene therapy as a new treatment method fordegenerative arthritis is demonstrated. After transfection of TGF-&bgr; cDNA expressionvectors into fibroblasts (NIH 3T3-TGF-&bgr;1), the cells were injected into rabbit achillestendon and knee joints with artificially-made cartilage defects. Intratendinous injectionswere performed to determine the optimal concentration for in vivo expression. Partiallydefected cartilage model was made to simulate degenerative arthritis of the knee joint.The partial cartilage defect treated with the cell-mediated gene therapy procedure wascovered by newly formed hyaline cartilage which indicates that the cells survived andstimulated matrix formation in this area. Completely denuded cartilage areas werecovered by fibrous collagen.
申请人：TISSUEGENE, INC.
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