专利名称：SYSTEMS AND METHODS FOR
INTRATHECAL DELIVERY OF APHARMACEUTICAL AGENT
发明人：HAYEK, Salim M.申请号：EP15705146.7申请日：20150128公开号：EP3102253A1公开日：20161214
摘要：An intrathecal delivery system for a pharmaceutical includes a reservoircontaining a volume of the pharmaceutical agent, and a pump configured to deliver aportion of the pharmaceutical agent contained in the reservoir. A controller is configuredto receive biological cycle information pertaining to a biological cycle (e.g., cardiac cycle),and configured, based on the received biological cycle information, to control the pumpto deliver the pharmaceutical agent into a patient's intrathecal space as a high-speedbolus at a time corresponding to a time determined based on Processing the biologicalcycle information. The high-speed bolus may be delivered at a rate of 10-100 μL persecond. The timing of such delivery corresponds to a time within the biological cyclewhen cerebrospinal fluid flow is optimal for intrathecal delivery of the pharmaceuticalagent. Conditions for which treatment is enhanced by the intrathecal delivery systeminclude refractory hypertension, spasticity and chronic pain management.
申请人：University Hospitals
地址：11100 Euclid Avenue Mather Pavilion B-270 Cleveland, Ohio 44106 US
国籍：US
代理机构：Ström & Gulliksson AB
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