Carboxylic acid derivatives, their production and

专利名称：Carboxylic acid derivatives, their production

and use

发明人：Nomura, Hiroaki,Akimoto, Hiroshi,Inoue,

Keizo,Imamiya, Eiko

申请号：EP89114597.1申请日：19890808公开号：EP0356765A2公开日：19900307

摘要：A compound represented by the formula: wherein R represents a hydrogenatom or a lower alkyl group; R¹ represents a higher alkyl group which may besubstituted; R² represents a hydrogen atom or a lower alkyl group, a lower alkanoylgroup or a nitrogen-containing 5- to 7-membered heterocyclic group each of which maybe substituted; X represents a divalent group represented by the formula: -(OCH₂CH₂)-wherein p represents an integer of 1 to 5, a divalent group represented by the formula: -O(CH₂)- wherein q represents an integer of 3 to 8, or a divalent group represented by theformula: -(OCH₂CH₂)-J-(CH₂)- wherein J represents an oxygen atom or a group

represented by the formula: -S(O)- (wherein r represents 0, 1 or 2), and p and q are thesame as defined above; Y represents a divalent group containing tertiary or quaternarynitrogen atom(s); and Z represents an alkylene group which may be substituted and/orinterrupted, or a group represented by the formula: -Q-T- or -T-W- wherein Q and Wrepresent an alkylene group which may be substituted, and T represents a phenylenegroup, a naphthylene group, a cycloalkylene group; and a salt thereof exhibit excellentantitumor action including differentiation inducing action and are useful as

pharmaceuticals.

申请人：Takeda Chemical Industries, Ltd.

地址：1-1, Doshomachi 4-chome Chuo-ku, Osaka JP

国籍：JP

代理机构：Casalonga, Axel

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