Polypeptides for the treatment of diseases

专利名称：Polypeptides for the treatment of diseases发明人：FORSSMANN, Wolf-Georg申请号：AU2018328044申请日：20180910

公开号：AU2018328044A1公开日：20200206

摘要：A polypeptide having the general amino acid sequence written in the singleletter code Z I X R W X X K X P X X S Z, wherein X = V, M or L, in particular L, X = S or T, X =K or R, in particular R, X = V, M, L or F, in particular M, X = Q or C, in particular C, X = V, Mor F, in particular V; Z= 0, Z, or pyro glutamate, wherein Z = is a modification of the N-terminal nitrogen atom of the peptide chain which modification forms together with theamino group of the N-terminal amino acid of the peptide a moiety having the structure -NRR wherein R and/or R are independently from each other H or a substituted orunsubstitued acyl, alkyl, aryl, aralkyl, cyclo alkyl and heterocyclo alkyl group; Z = 0, or Z,wherein Z = is a modification of the C-terminal carboxyl group of the peptide chain, whichmodification forms together with the carboxyl group of the C-terminal amino acid of thepeptide a moiety having the structure -C(O)-O-R or -C(O)- NRR, wherein R is a substitutedor unsubstitued alkyl, aryl, aralkyl, cyclo alkyl and heterocyclo alkyl group; and R and Rare defined as above.

申请人：Neopep Pharma GmbH & Co. KG

代理人：Davies Collison Cave Pty Ltd

更多信息请下载全文后查看